C-g quit
C-x C-x Exit
C-x C-f open / "visit" a file
C-x k kill the buffer representing a file... not deleting a file

C-f move forward one character
C-b move back
M-f move forward one word
M-b move back one word

C-d Delete a character
M-d Delete a word
C-_ Undo

C-p previous line / up
C-n next line / down
C-a move to the beginning of the a line
C-e move to the end of the line

M-< begging of the buffer
M-> end of the file
C-v page down
M-v page up
C-l center the screen 

C-x 2 split top/bottom 
C-x o other window 
C-x 3 split left right
C-x 1 remove all windows - simplify life

Search
C-s text  <--- search
C-s Text  <--- case sensitive search

C-space <--- start / toggle marking a region
C-k kill to end of line
M-w copy
C-w cut
C-y yank / paste

M-x query-replace
M-%
M-$ spell check word
Hello Worlds
M-x flyspell-mode
Hello Worlds